KAl(SO4)2·12H2O (Alum) Catalyzed One-Pot Three-Component Synthesis of 2-Alkyl and 2-Aryl-4(3H)-quinazolinone under Microwave Irradiation and Solvent Free Conditions
Twenty 2,3‐disubstituted‐4(3H)‐quinazolinones were synthesed by one‐pot three‐component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO4)2·12H2O (Alum) under microwave irradiation and solvent‐free conditions. 6‐Bromo‐2‐propyl‐3‐p‐tolylquinazolin‐4(3H)...
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Published in | Chinese journal of chemistry Vol. 29; no. 9; pp. 1982 - 1984 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.09.2011
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Twenty 2,3‐disubstituted‐4(3H)‐quinazolinones were synthesed by one‐pot three‐component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO4)2·12H2O (Alum) under microwave irradiation and solvent‐free conditions. 6‐Bromo‐2‐propyl‐3‐p‐tolylquinazolin‐4(3H)‐one (4m), 6‐bromo‐2‐methyl‐3‐phenethylquinazolin‐4(3H)‐one (4n) and 6‐bromo‐2‐ethyl‐3‐phenethylquinazolin‐4(3H)‐one (4o) were characterized by IR, 1H NMR, 13C NMR and elemental analysis.
Twenty 2,3‐disubstituted‐4(3H)‐quinazolinones were synthesed by one‐pot three‐component method with isatoic anhydride, orthoesters and amines as raw materi‐als in the presence of KAl(SO4)2·12H2O (Alum) under microwave irradiation and solvent‐free conditions. 6‐Bromo‐2‐propyl‐3‐p‐tolylquinazolin‐4(3H)‐one (4m), 6‐bromo‐2‐methyl‐3‐phenethylquinazolin‐4(3H)‐one (4n) and 6‐bromo‐2‐ethyl‐3‐phenethylquina‐zolin‐4(3H)‐one (4o) were characterized by IR, 1H NMR, 13C NMR and elemental analysis. |
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Bibliography: | istex:B12A4F0D7001E14ECF9B81D19550046807A96BF6 ArticleID:CJOC201180344 ark:/67375/WNG-K5LQWMBF-6 |
ISSN: | 1001-604X 1614-7065 |
DOI: | 10.1002/cjoc.201180344 |