siRNA Delivery: Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016)

Supramolecular dendrimers created from small amphiphilic dendrons are able to mimic covalently constructed high‐generation dendrimers for siRNA delivery, as presented by S. Pricl, L. Peng, and co‐workers on page 3667. An optimal balance between the hydrophobic alkyl chain length and the hydrophilic...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 12; no. 27; p. 3604
Main Authors Chen, Chao, Posocco, Paola, Liu, Xiaoxuan, Cheng, Qiang, Laurini, Erik, Zhou, Jiehua, Liu, Cheng, Wang, Yang, Tang, Jingjie, Col, Valentina Dal, Yu, Tianzhu, Giorgio, Suzanne, Fermeglia, Maurizio, Qu, Fanqi, Liang, Zicai, Rossi, John J., Liu, Minghua, Rocchi, Palma, Pricl, Sabrina, Peng, Ling
Format Journal Article
LanguageEnglish
Published Weinheim Blackwell Publishing Ltd 20.07.2016
Wiley Subscription Services, Inc
Subjects
amphiphilic dendrons
nanomicelles
Nanotechnology
self-assembly
siRNA delivery
supramolecular dendrimers
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Summary:Supramolecular dendrimers created from small amphiphilic dendrons are able to mimic covalently constructed high‐generation dendrimers for siRNA delivery, as presented by S. Pricl, L. Peng, and co‐workers on page 3667. An optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion is crucial for self‐assembly of these amphiphilic dendrons into micellar nanostructures, and critically impacts the effectiveness of siRNA delivery and functional gene silencing.
Bibliography:ArticleID:SMLL201670131
istex:B06FBB9255B0B4A40DCDD31E86678C208A94337C
ark:/67375/WNG-G593ZPNF-6
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201670131