Oxidative Stress in Cancer

• Published in: Nutraceuticals in Cancer Prevention, Management, and Treatment pp. 99 - 111
• Main Authors: Hussain, Muhammad Bilal, Ahmad, Rabia Shabir, Hassan, Sadia, Waheed, Marwa, Javed, Amna
• Format: Book Chapter
• Language: English
• Published: United Kingdom Apple Academic Press 2024; Apple Academic Press, Incorporated
• Edition: 1
• Subjects: Antioxidant Defense System; Oxidize DNA; Transition Metals; Mitogenic Response; Detoxification Of Hydrogen Peroxide; Postprandial Oxidative Stress; RNA Oxidation; RNS; DNA Mutation; reactive oxygen species; reactive nitrogen species; DNA Deterioration; free radicals; Oxidative DNA Damage; Protein Oxidation; S Carboxymethyl Cysteine; DNA Damage Response; Low Molecular Weight Thiols; DNA Repair Mechanism; Chronic; ROS; cancer; DNA Damage; Lipid Peroxidation; oxidative stress; High OPP; NADPH Oxidase
• ISBN: 1774913283; 9781774913284; 1774913275; 9781774913277
• DOI: 10.1201/9781003392552-5

Free radicals have secured immense importance in biological studies owing to their role in different physiological conditions and their implications in numerous life-threatening maladies. Free radicals including ROS (reactive oxygen species) and RNS (reactive nitrogen species) are derived both from internal sources (endoplasmic reticulum, mitochondria, peroxisomes, etc.) and from external ones (tobacco smoke, alcohol, pollution, heavy metals, etc.). They can severely affect various biological molecules, which are of key importance, such as lipids, proteins, and nucleic acids, resultantly alter the normal redox status of the body causing increased oxidative stress. This condition is believed to be responsible for a disease like neurodegenerative disorder, cardiovascular diseases, diabetes mellitus, and various types of cancers.