A Statistical and Biological Approach for identifying misdiagnosis of incipient Alzheimer patients Using Gene expression Data

• Published in: 2006 International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2006; pp. 5854 - 5857
• Main Authors: Joseph, S., Robbins, K.R., Rekaya, R.
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 2006
• Subjects: Algorithms; alpha-Synuclein - biosynthesis; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animals; Apolipoprotein E4 - metabolism; Bioinformatics; Biological system modeling; Computational Biology - methods; Degenerative diseases; Dementia; Diagnosis, Computer-Assisted; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Genetics; Humans; Models, Statistical; Models, Theoretical; Predictive models; Probes; Reproducibility of Results; Transcription, Genetic
• ISBN: 9781424400324; 1424400325
• ISSN: 1557-170X
• DOI: 10.1109/IEMBS.2006.259371

A latent-threshold model and misclassification algorithm were implemented to examine potential misdiagnosis among 16 Alzheimer's disease (AD) subjects using gene expression data. Results obtained without invoking the misclassification algorithm showed limited predictive power of the model. When the misclassification algorithm was invoked, four subjects were identified as being potentially misdiagnosed. Results obtained after adjustment of the AD status of these four samples showed a significant increase in the model's predictive ability. Mixed model analysis detected no AD related genes as differentially expressed when using original classifications; conversely, multiple AD genes were identified using the new classifications. These results suggest that this algorithm can identify misclassified subjects which, in turn, can increase power to predict disease status and identify disease related genes