Live Demonstration: A Lab-on-Chip Platform for Dynamic Biosensing of Fluids

We present a comprehensive Lab-on-Chip platform that integrates a CMOS ISFET array with a 3D-printed microfluidic flow cell. The sensing front end is a System-on-Chip, fabricated using an unmodified CMOS technology, which monolithically integrates the sensing array and its instrumentation circuits....

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Bibliographic Details
Published inBiomedical Circuits and Systems Conference p. 1
Main Authors Kuang, Lei, Zeng, Junming, Boutelle, Martyn, Georgiou, Pantelis
Format Conference Proceeding
LanguageEnglish
Published IEEE 24.10.2024
Subjects
Arrays
Lab-on-a-chip
Microfluidics
Monitoring
Pumps
Real-time systems
Regulation
Sensors
Temperature control
Temperature sensors
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ISSN2766-4465
DOI10.1109/BioCAS61083.2024.10798408

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Summary:We present a comprehensive Lab-on-Chip platform that integrates a CMOS ISFET array with a 3D-printed microfluidic flow cell. The sensing front end is a System-on-Chip, fabricated using an unmodified CMOS technology, which monolithically integrates the sensing array and its instrumentation circuits. A dedicated FPGA-based digital readout system manages data acquisition, buffering, and transmission. The platform supports temperature regulation through a feedback control loop and uses a peristaltic pump for monitoring samples across the ISFET sensing array during dynamic flow, allowing real-time investigation of ion reactions on the surface.
ISSN:2766-4465
DOI:10.1109/BioCAS61083.2024.10798408