A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control

We propose a model-free artificial pancreas (AP) for people with type 1 diabetes. The algorithmic parameters are tuned to a virtual population of 1,000,000 individuals, and the AP repeatedly estimates the basal and bolus insulin requirements necessary for maintaining normal blood glucose levels. The...

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Bibliographic Details
Published in2023 European Control Conference (ECC) pp. 1 - 6
Main Authors Tobias K. S., Ritschel, Reenberg, Asbjorn Thode, Lindkvist, Emilie B., Laugesen, Christian, Svensson, Jannet, Ranjan, Ajenthen G., Norgaard, Kirsten, Dammann, Bernd, Jorgensen, John Bagterp
Format Conference Proceeding
LanguageEnglish
Published EUCA 13.06.2023
Subjects
Atmospheric measurements
Clinical trials
Diabetes
Glucose
Pancreas
Particle measurements
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Summary:We propose a model-free artificial pancreas (AP) for people with type 1 diabetes. The algorithmic parameters are tuned to a virtual population of 1,000,000 individuals, and the AP repeatedly estimates the basal and bolus insulin requirements necessary for maintaining normal blood glucose levels. Therefore, the AP can be used without healthcare personnel or engineers customizing the algorithm to each user. The estimates are based on bodyweight, measurements from a continuous glucose monitor (CGM), and estimates of the meal carbohydrate contents. In a virtual clinical trial with a111,000,000 individuals (i.e., a Monte Carlo closed-loop simulation), the AP achieves a mean time in range of more than 87% and over 88% of the participants satisfy several glycemic targets.
DOI:10.23919/ECC57647.2023.10178186