Real and complex genomic signals

The paper discusses the ways of converting DNA sequences from their symbolic - nucleotide, codon and amino acid - forms into corresponding digital signals. It is shown that all the real and complex mappings can be derived from the same original tetrahedral representation of the genetic code (GC). Th...

Full description

Saved in:
Bibliographic Details
Published in2002 14th International Conference on Digital Signal Processing Proceedings. DSP 2002 (Cat. No.02TH8628) Vol. 2; pp. 543 - 546 vol.2
Main Author Cristea, P.
Format Conference Proceeding
LanguageEnglish
Published IEEE 2002
Subjects
Amino acids
Bioinformatics
Digital signal processing
DNA
Genetics
Genomics
Sequences
Signal analysis
Signal mapping
Signal processing
Online AccessGet full text

Cover

More Information
Summary:The paper discusses the ways of converting DNA sequences from their symbolic - nucleotide, codon and amino acid - forms into corresponding digital signals. It is shown that all the real and complex mappings can be derived from the same original tetrahedral representation of the genetic code (GC). The reduction of the representation dimensionality results from the projection of the GC tetrahedron on adequately oriented planes or surfaces. On these bases, optimal symbolic-to-digital mappings of the DNA strands into real or complex genomic signals are derived at nucleotide, codon and amino acid levels. By converting the nucleic acid and polypeptide sequences into digital genomic signals, this approach offers the possibility to use a large variety of signal processing methods for their handling and analysis. It is also shown that some essential features of the nucleotide sequences can be better extracted using this representation. Results obtained by applying this approach for the analysis of the human genome are presented along with some new methods for identifying genetically significant segments of DNA sequences.
ISBN:9780780375031
0780375033
DOI:10.1109/ICDSP.2002.1028147