Optimizing sequential dual tracer P.E.T. studies using a combined 2D/3D imaging protocol

• Published in: IEEE Symposium Conference Record Nuclear Science 2004 Vol. 6; pp. 3357 - 3360 Vol. 6
• Main Authors: Wilson, J.W., Turkington, T.G., Colsher, J.G., Borges-Neto, S., Reiman, R.E., Coleman, R.E.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 2004
• Subjects: Biomedical imaging; Contamination; Imaging phantoms; Ischemic pain; Medical services; Myocardium; Protocols; Radiology; Telephony; Torso
• ISBN: 9780780387003; 0780387007
• ISSN: 1082-3654; 2577-0829
• DOI: 10.1109/NSSMIC.2004.1466452

We have investigated a combined 2D/3D protocol for minimizing contamination in dual tracer P.E.T. studies in which the tracers are administered on a timescale that is short compared to the half-lives. We have performed a series of phantom studies on an Advance and a Discovery ST (GE Healthcare Technologies), using a torso phantom with cardiac insert (Data Spectrum Corporation) to simulate a combined FDG and NH/sub 3/ scan protocol for a patient with ischemia. The phantom was imaged in a series of alternating 2D/3D acquisitions as it decayed over 6 half-lives. By comparing 2D and 3D images, we have verified that 3D images are of comparable accuracy to 2D images, even with realistic out-of-field activity challenging the 3D scans. Based on scan and image statistical quality, we have recommended optimal doses for maximizing the image quality of both scans.