Gelam (Melaleuca sp.) honey demonstrates antiproliferative effect on colon cancer cell lines (HCT116)

Colorectal cancer is among the highest prevalence cancer worldwide. As current treatments have many side effects, there is a need to find a better cure that is non-toxic and has no undesirable side effects. Honey is found to be a potential cure. Thus, antiproliferative effect of Gelam honey to colon...

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Bibliographic Details
Published in2012 IEEE Symposium on Business, Engineering and Industrial Applications pp. 362 - 364
Main Authors Fadhli, M. R. Mohd Naim, Noorfathiah, I., Hana, M. A. Nurul Farah, Ashraf, M. S. Muhammad, Zolkapli, E., Mizaton, H. H., Iryani, W. I. Wan
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.09.2012
Subjects
antiproliferative effects
Artificial intelligence
Business
Colon (HCT116) cancer cell lines
IC 50
Iron
TPC
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Summary:Colorectal cancer is among the highest prevalence cancer worldwide. As current treatments have many side effects, there is a need to find a better cure that is non-toxic and has no undesirable side effects. Honey is found to be a potential cure. Thus, antiproliferative effect of Gelam honey to colon (HCT116) cancer cell lines was studied. HCT116 was treated with Gelam honey and observed under inverted microscope. Then, total phenolic content (TPC), percentage cell death and half-maximal inhibitory concentrations (IC 50 ) of cells treated with the honey were observed. HCT116 shows great reduction in number of cells (IC 50 = 2.0 v/v for 72 hours) with presence of high total phenolic content (0.12 mg GAE/100 g). In conclusion, the amount of cell death observed has a significant relationship with doses and time of treatment. Thus, Gelam honey can indeed be a potential new cure for colorectal cancer treatment.
ISBN:9781457716324
1457716321
DOI:10.1109/ISBEIA.2012.6422904