Ultrasonic transport of particles into articular cartilage and subchondral bone

Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro- and nano-particles (MNPS) into three bovin...

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Bibliographic Details
Published in2012 IEEE International Ultrasonics Symposium pp. 1869 - 1872
Main Authors Nieminen, H. J., Herranen, T., Kananen, V., Hacking, S. A., Salmi, A., Karppinen, P., Haeggstrom, E.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.2012
Subjects
Acoustics
Bones
Joints
Microscopy
Protocols
Surface treatment
Ultrasonic imaging
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Summary:Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro- and nano-particles (MNPS) into three bovine osteochondral samples: (1) control (C) that was exposed to the particles without sonication, (2) UST-1 that was sonicated prior to immersion in a MNPS and (3) UST-2 that was sonicated in the presence of MNPS. Following treatment samples were cut into 2.9 ± 0.3 mm sections and digital images were obtained by light microscopy. In the sonicated samples (UST-1 and UST-2) MNPS penetrated into articular cartilage and subchondral bone. No MNPS penetration was observed in C. The proposed technique could potentially be used for local drug treatment of OA.
ISBN:9781467345613
146734561X
ISSN:1051-0117
DOI:10.1109/ULTSYM.2012.0469