Analysis of the emergence of drug resistant HIV for drug scheduling methods

HIV/AIDS drug therapies, including highly active anti-retroviral therapy (HAART), often fail because of the emergence of drug resistant mutation. We research a new evaluation method for the possibility of the resistant emergence in this paper. We suggest a quantitative estimation method to evaluate...

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Bibliographic Details
Published inCDC : 2017 IEEE 56th annual Conference on Decision and Control : 12-15 December 2017 pp. 4112 - 4117
Main Author Hyuk-Jun Chang
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.12.2017
Subjects
Drugs
Human immunodeficiency virus
Immune system
Mathematical model
Schedules
Switches
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Summary:HIV/AIDS drug therapies, including highly active anti-retroviral therapy (HAART), often fail because of the emergence of drug resistant mutation. We research a new evaluation method for the possibility of the resistant emergence in this paper. We suggest a quantitative estimation method to evaluate this possibility for antiretroviral drug treatment of HIV infection. By doing so, this paper reports research on quantitative description of the emergence of drug resistant HIV for drug therapies. By means of simulation studies we compare HIV/AIDS therapies by applying the evaluation method to the therapies.
DOI:10.1109/CDC.2017.8264263