Intermodal registration of CTA and IVUS-VH, and its application on CTA-based plaque composition analysis
Plaque composition analysis is a critical tool in identifying vulnerable atherosclerotic plaques. Intravascular ultrasound with spectral analysis of the backscattered radio frequency (RF) signals (IVUS-VH) is currently considered as the gold standard for the evaluation of coronary plaque composition...
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Published in | 2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro pp. 419 - 423 |
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Main Authors | , , |
Format | Conference Proceeding |
Language | English |
Published |
IEEE
01.03.2011
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Subjects | |
Online Access | Get full text |
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Summary: | Plaque composition analysis is a critical tool in identifying vulnerable atherosclerotic plaques. Intravascular ultrasound with spectral analysis of the backscattered radio frequency (RF) signals (IVUS-VH) is currently considered as the gold standard for the evaluation of coronary plaque composition, while CT coronary angiography (CTA) has been proposed as a potential non-invasive counterpart. In this paper, we have developed a novel intermodal registration framework for IVUS-VH and CTA, which is based on a novel composition-to-appearance transformation technique and a mutual-information-based registration algorithm. A detailed and complete intermodal registration system was presented. In addition, based on the registered images, we have developed a principal component analysis-based plaque composition classification tool, which has been tested and validated on 6 sets of IVUS-VH and CTA images. Experimental results have shown that our approach has the potential of improving the classification accuracy of plaque compositions on CTA. |
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ISBN: | 1424441277 9781424441273 |
ISSN: | 1945-7928 1945-8452 |
DOI: | 10.1109/ISBI.2011.5872436 |