High sensitive protein fluorescence sensing on nano ring gap (NRG) LSPR sensor

This paper proposes a novel nanosensing platform for protein fluorescence enhancement by nano ring gap (NRG) induced localized surface plasma resonance (LSPR). On this platform, gold nanoparticles (GNPs) surrounded by silver sheathes with a nanosized gap were designed and successfully fabricated for...

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Published in2010 IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS) pp. 879 - 882
Main Authors Tsung-Yen Lee, Shen-Shiun Wu, Wei-Kuo Chang, Pei-Kuen Wei, Fan-Gang Tseng
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.01.2010
Subjects
Background noise
Economic indicators
Fluorescence
Gold
Nanoparticles
Optical polarization
Optical surface waves
Protein engineering
Resonance
Silver
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Summary:This paper proposes a novel nanosensing platform for protein fluorescence enhancement by nano ring gap (NRG) induced localized surface plasma resonance (LSPR). On this platform, gold nanoparticles (GNPs) surrounded by silver sheathes with a nanosized gap were designed and successfully fabricated for protein immobilization/detection. Through simulation, when the nano ring gap between silver sheath and gold nanoparticle reduced to 15 nm, the light intensity can be enhanced by around 8.5 folds of magnitude than that of the 5 nm gap sensor. Experiment result has also verified the fluorescence enhancement by 7 fold for bound protein on GNPs. This platform will be further tailored for single protein molecule detection in the future.
ISBN:1424457610
9781424457618
ISSN:1084-6999
DOI:10.1109/MEMSYS.2010.5442347