Millimeter-wave non-invasive monitoring of glucose in anesthetized rats

The realization of a non-invasive monitor for determining blood glucose concentrations in human subjects is a prescient driver for many new techniques spanning optical, chemical, electronic and radio sensors. Microwaves offer the possibility of simple, compact, non-invasive, and continuous measureme...

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Bibliographic Details
Published inInternational Conference on Infrared, Millimeter, and Terahertz Waves (Print) pp. 1 - 2
Main Authors Siegel, Peter H., Yoon Lee, Pikov, Victor
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.09.2014
Subjects
Absorption
Blood
Insulin
Microwave FET integrated circuits
Microwave theory and techniques
Monitoring
Sugar
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ISSN2162-2027
DOI10.1109/IRMMW-THz.2014.6956294

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Summary:The realization of a non-invasive monitor for determining blood glucose concentrations in human subjects is a prescient driver for many new techniques spanning optical, chemical, electronic and radio sensors. Microwaves offer the possibility of simple, compact, non-invasive, and continuous measurement of glucose level in superficial tissue layers without significant heating, enzymatic reactions, or any short or long term deleterious effects on the tissue. This paper demonstrates the first real-time direct correlative measurements of the blood glucose concentration (using commercial blood test strips) and millimeter-wave (MMW) absorption during intraperitoneal injections of glucose, insulin, and saline in a live anesthetized animal. MMW transmission and reflection in the Ka band (27-40 GHz) was measured with a commercial vector network analyzer and non-invasive waveguides positioned on the ear. The data shows strong correlation between the blood glucose levels and MMW absorption during the experimentally induced hyper- and hypoglycemia.
ISSN:2162-2027
DOI:10.1109/IRMMW-THz.2014.6956294