Three-dimensional tracing of neurites in fluorescence microscopy images using local path-finding

Neurite tracing in 3D neuron images is important when it comes to analysing the growth and functionality of nerve cells. The methods used today are either of high complexity, limiting throughput, or semi-automatic, i.e., requiring user interaction. This makes them unsuitable for analysis where high...

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Bibliographic Details
Published in2010 IEEE International Conference on Acoustics, Speech and Signal Processing pp. 646 - 649
Main Authors Gedda, M, Vallotton, P
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.03.2010
Subjects
Design methodology
Feature extraction
Fluorescence
Image analysis
Imaging phantoms
Large-scale systems
Microscopy
neurite
Neurons
path-finding
Software packages
Throughput
Tracing
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Summary:Neurite tracing in 3D neuron images is important when it comes to analysing the growth and functionality of nerve cells. The methods used today are either of high complexity, limiting throughput, or semi-automatic, i.e., requiring user interaction. This makes them unsuitable for analysis where high throughput is needed. In this work we propose a method designed for low complexity and void of user interaction by using local path-finding. The method is illustrated on both phantom and real data, and compared with a widely used commercial software package with promising results.
ISBN:9781424442959
1424442958
ISSN:1520-6149
2379-190X
DOI:10.1109/ICASSP.2010.5495143