Detecting brain shift during deep brain stimulation surgery using intra-operative data and functional atlases: A preliminary study

• Published in: 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro pp. 362 - 365
• Main Authors: Pallavaram, S., D'Haese, P.-F., Remple, M.S., Neimat, J.S., Kao, C., Rui Li, Konrad, P.E., Dawant, B.M.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 01.06.2009
• Subjects: Brain stimulation; Computed tomography; Computer science; Deep brain stimulation; Electrodes; functional atlases; intra-operative brain shift; Magnetic resonance imaging; Microelectrodes; Neurosurgery; Satellite broadcasting; statistical maps; Surgery; Target tracking
• ISBN: 1424439310; 9781424439317
• ISSN: 1945-7928; 1945-8452
• DOI: 10.1109/ISBI.2009.5193059

Recently, many groups have reported on the occurrence of brain shift in stereotactic surgery and its impact on the procedure. A shift of deep brain structures by only a few millimeters can potentially increase the number of required microelectrode and/or macroelectrode tracks. This can cause complications and potentially affect implantation accuracy. Detecting intra-operative brain shift and, more significantly correcting for it intra-operatively can thus impact the procedure and its outcome. In this study, we have used intra-operative stimulation response data to assess brain shift. Using a shift free functional atlas containing therapeutic response to stimulation (efficacy) data from a population of patients we build statistical efficacy maps on new patients. We then compare the information provided by the maps with the actual intra-operative responses of those patients to detect brain shift. Our preliminary results show that by maximizing the correlation between statistical maps and intra-operative observations, it may be possible to detect intra-operative brain shift and potentially correct for it.