UKF-based state feedback control of abnormal neural oscillations in demyelination symptom

Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically excessive spiking that underlies the symptoms observed in demyelination diseases. Feedback control via functional electrical stimulation (FES)...

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Bibliographic Details
Published inProceedings of the 10th World Congress on Intelligent Control and Automation pp. 4984 - 4988
Main Authors Qitao Jin, Jiang Wang, Bin Deng, Xile Wei, Feng Dong, Huiyan Li, Yanqiu Che
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.07.2012
Subjects
Biological system modeling
Biomembranes
Demyelination symptom
Equations
Feedback control
functional electrical stimulation
Mathematical model
Neurons
State feedback
state feedback control
Unscented Kalman filter
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Summary:Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically excessive spiking that underlies the symptoms observed in demyelination diseases. Feedback control via functional electrical stimulation (FES) seems to be a promising treatment modality in such diseases. However, there are challenges to implementing such method for neurons: high nonlinearity, biological tissue constrains and unobservable ion channel states. To address this problem, we propose an estimating and tracking control strategy for systems based on Kalman filter, in order to enhance the action potential propagation reliability of demyelinated neuron via FES. Our method could promote the design of new closed-loop electrical stimulation systems for patients suffering from different nerve system dysfunctions.
ISBN:9781467313971
1467313971
DOI:10.1109/WCICA.2012.6359423