Synthesis of [3′-14C] coenzyme Q10

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 45; no. 10; pp. 823 - 829
• Main Authors: Hamamura, Kimio, Yamatsu, Isao, Minami, Norio, Yamagishi, Yoji, Inai, Yuichi, Kijima, Shizumasa, Nakamura, Tetsuya
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2002; Wiley
• Subjects: [3-14C]decaprenol; [3′-14C]coenzyme Q10; Chemistry; ethyl [3-14C]acetoacetate; Exact sciences and technology; Noncondensed benzenic compounds; Organic chemistry; Preparations and properties; solanesol; triethyl phosphonoacetate; Wittig reaction; Ubiquinone; Radiolabelling; Quinone; Ketoester; Isoprenoid; Chemical synthesis; Carbon 14
• ISSN: 0362-4803; 1099-1344
• DOI: 10.1002/jlcr.588

Radio‐labelled coenzyme Q10, labelled at the 3′‐position with 14C, was synthesized starting from natural solanesol and ethyl [3‐14C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐14C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. The specific radioactivity and radiochemical purity are sufficiently high to enable us to use this labelled form of coenzyme Q10 in metabolic studies. Copyright © 2002 John Wiley & Sons, Ltd.