Model-Based Control of Biochemical Reactors

• Published in: The Control Handbook pp. 519 - 534
• Format: Book Chapter
• Language: English
• Published: United Kingdom CRC Press 2011; Taylor & Francis Group
• Subjects: Electronics engineering; ENVIRONMENTAL ENGINEERING & TECHNOLOGY; SCIENCE: GENERAL ISSUES; Input Output Linearization; Feed Flow Rate; Anaerobic Growth; State Dependent Constraints; Bioreactor Control; Cellular Biomass; Open Loop Optimization; Fed Batch Operation; Continuous Bioreactor; Growth Rate Function; Dilution Rate; Bioreactor Model; Feed Substrate Concentration; Dynamic Optimization Approach; Concentration Sf; Ethanol Productivity; Renewable Liquid Fuel; Nonlinear Optimization Codes; Volumetric Feed Flow Rate; Ordinary Differential Equations; Cellular Growth; Model Based Control Strategies; Model Based Controller Design; Feeding Profiles; Fed Batch Bioreactor
• ISBN: 9781420073607; 1420073605
• DOI: 10.1201/b10382-29

The biotechnology industry is expanding rapidly due to continuing advances in the understanding of complex biological systems and the high demand for biologically manufactured products such as foods andbeverages, pharmaceuticals, and commodity and specialty chemicals. The impact of the biotechnology industry on the global economy is substantial. For example, the revenues of the top 10U.S. pharmaceutical manufacturers totaled USD 217 billion in 2002 with profits of USD 36 billion [1]. A rapidly growing biotechnology market is the large-scale production of ethanol as a renewable liquid fuel. The production of ethanol in 1998 was 31.2 billion liters worldwide and 6.4 billion liters in the United States with roughly two-thirds of the ethanol produced targeted for biofuel applications [2].