Isonicotinoylhydrazide modified 3-acetylcoumarin scaffold as an efficient chemical reversible sensor to detect Al3+ selectively and its application in live cells imaging

A turn-on photochromic sensor based on coumarin was designed and synthesized for selective and sensitive detection of Aluminium(III) (Al 3+ ) in ethanol (C 2 H 5 OH)/water (H 2 O; 1:1, v/v) with the detection limit of 0.126 μM. The mechanism was proposed to form a kind of 1:1-type complex between pr...

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Bibliographic Details
Published inSynthetic communications Vol. 49; no. 19; pp. 2501 - 2511
Main Authors Wang, Wenling, Jin, Lei, Kuang, Yang, Yuan, Zhongzhong, Wang, Qingming
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 02.10.2019
Taylor & Francis Ltd
Subjects
Aluminum
cell imaging
Coumarin
Ethanol
Fluorescent probe
limit of detection
mechanism
Organic chemistry
Sensors
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Summary:A turn-on photochromic sensor based on coumarin was designed and synthesized for selective and sensitive detection of Aluminium(III) (Al 3+ ) in ethanol (C 2 H 5 OH)/water (H 2 O; 1:1, v/v) with the detection limit of 0.126 μM. The mechanism was proposed to form a kind of 1:1-type complex between probe C1 and Al 3+ in which the binding constant was 3.11 × 10 7 M −1 . In addition, the sensor was effectively used for the detection of Al 3+ in living HEK293T cells. A new "turn-on" chemodosimeter exhibited instant / reversible and excellent specificity towards Al 3+ in aqueous media and living cells.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2019.1631345