Optimized 31P MRS in the human brain at 7 T with a dedicated RF coil setup
The design and construction of a dedicated RF coil setup for human brain imaging (1H) and spectroscopy (31P) at ultra‐high magnetic field strength (7 T) is presented. The setup is optimized for signal handling at the resonance frequencies for 1H (297.2 MHz) and 31P (120.3 MHz). It consists of an eig...
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Published in | NMR in biomedicine Vol. 28; no. 11; pp. 1570 - 1578 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Blackwell Publishing Ltd
01.11.2015
John Wiley and Sons Inc |
Subjects | |
Online Access | Get full text |
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Summary: | The design and construction of a dedicated RF coil setup for human brain imaging (1H) and spectroscopy (31P) at ultra‐high magnetic field strength (7 T) is presented. The setup is optimized for signal handling at the resonance frequencies for 1H (297.2 MHz) and 31P (120.3 MHz). It consists of an eight‐channel 1H transmit–receive head coil with multi‐transmit capabilities, and an insertable, actively detunable 31P birdcage (transmit–receive and transmit only), which can be combined with a seven‐channel receive‐only 31P array. The setup enables anatomical imaging and 31P studies without removal of the coil or the patient. By separating transmit and receive channels and by optimized addition of array signals with whitened singular value decomposition we can obtain a sevenfold increase in SNR of 31P signals in the occipital lobe of the human brain compared with the birdcage alone. These signals can be further enhanced by 30 ± 9% using the nuclear Overhauser effect by B1‐shimmed low‐power irradiation of water protons. Together, these features enable acquisition of 31P MRSI at high spatial resolutions (3.0 cm3 voxel) in the occipital lobe of the human brain in clinically acceptable scan times (~15 min). © 2015 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.
A coil setup for 31P MRSI at 7 T is presented. The setup consists of an eight‐channel 1H head coil, a 31P detunable birdcage, and a seven‐channel 31P receive array. Separating transmission and reception of 31P led to a local sevenfold increase in SNR. An additional gain in SNR was achieved by an optimal signal combination of the receive array (WSVD). 31P signals could be further increased by approximately 30% using NOE enhancement. This enables acquisition of 31P spectra from 3 cm3 voxels in 15 min. |
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Bibliography: | ark:/67375/WNG-6Z4S8FG9-D ArticleID:NBM3422 istex:5E82236927C42BF4232A5D61A48FADCF17D4D5A3 |
ISSN: | 0952-3480 1099-1492 |
DOI: | 10.1002/nbm.3422 |