Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis

Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothel...

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Published in2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) pp. 1 - 4
Main Authors Weng, Julia Tzu-Ya, Yi-Cheng Chen, Chung-Hsien Ma, Tzung-Shian Lai, Feng-Ming Ho
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.04.2014
Subjects
Bioinformatics
Diabetes
Diseases
Gene expression
high glucose
RNA
Sugar
time-course analysis
Veins
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Summary:Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.
DOI:10.1109/ISBB.2014.6820924