Plasma neutrophil lipocalin, elastase-α1-antitrypsin complex and neutrophil protease 4 in preterm infants with respiratory distress syndrome

• Published in: Scandinavian journal of clinical and laboratory investigation Vol. 63; no. 2; pp. 89 - 92
• Main Authors: SVEGER, T., OHLSSON, K., MÖRSE, H., POLBERGER, S., LAURIN, S.
• Format: Journal Article
• Language: English
• Published: Oslo Taylor & Francis 01.01.2003; Scandinavian University Press
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; chronic lung disease of prematurity; elastase; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Intensive care medicine; Medical sciences; neutrophil lipocalin; neutrophil protese 4; Pneumology; Respiratory system : syndromes and miscellaneous diseases; α1-antitrypsin; Human; Leukocyte elastase; Premature; Serine endopeptidases; Respiratory disease; Enzyme; Infant; α1-Antitrypsin; Blood plasma; Peptidases; Hydrolases; Respiratory distress; Neutrophil
• ISSN: 0036-5513; 1502-7686
• DOI: 10.1080/00365510310000961

Respiratory distress syndrome (RDS) and chronic lung disease of prematurity (CLD) are associated with inflammation of the airways and interstitial tissue of the lung. It is hypothesized that RDS severity and the risk of developing CLD may be correlated with neutrophil gelatinase-associated lipocalin (NGAL), a marker of leucocyte activity, human elastase-α 1 -antitrypsin complex (HEAT) or free and complexed neutrophil protease 4 (NP4), markers of proteolytic enzyme secretion from granulocytes. Thirty-three preterm infants with RDS were enrolled in the study and plasma sampled between 3 and 14 days of life. NGAL, HEAT and NP4 concentrations varied widely in infants with RDS. Significant correlations between subsequent development of CLD and plasma concentrations of HEAT and NP4, respectively, were found on days 3-4 of life, p=0.006 and p=0.02, respectively.