Influence of hydrocortisone on uptake and elimination of 32P-labelled E. coli by rat polymorphonuclear neutrophils (PMN) in vitro

Hydrocortisone was tested for inhibition of uptake and of elimination of E. coli by monolayers of rat peritoneal PMN. 32P was used as label of the bacteria and their degradation products eliminated from the phagocytes. The cellular uptake was reduced by hydrocortisone (1-2 mg per ml) both in the pre...

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Published inActa pathologica et microbiologica Scandinavica. Section C. Immunology Vol. 84; no. 2; p. 131
Main Author Baardsen, A
Format Journal Article
LanguageEnglish
Published Denmark 01.11.1976
Subjects
Animals
Depression, Chemical
Escherichia coli
Hydrocortisone - pharmacology
Neutrophils - drug effects
Phagocytosis - drug effects
Phosphorus Radioisotopes
Rats
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Summary:Hydrocortisone was tested for inhibition of uptake and of elimination of E. coli by monolayers of rat peritoneal PMN. 32P was used as label of the bacteria and their degradation products eliminated from the phagocytes. The cellular uptake was reduced by hydrocortisone (1-2 mg per ml) both in the presence and absence of serum, while the elimination of bacterial label was reduced by 0.5 mg per ml and higher concentrations of the drug.
ISSN:0304-1328
DOI:10.1111/j.1699-0463.1976.tb00010.x