B12-retro-Riboswitches: Constitutional Switching of B12 Coenzymes Induced by Nucleotides

A vitamin that switches states: The appended nucleotide base B assists in the constitutional switch from the base‐on form of the B12 conjugate (blue, with a coordinated 5,6‐dimethylbenzimidazole (DMB) unit) to the base‐off form (red, with a free DMB unit). The process is strongly temperature depende...

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Published inAngewandte Chemie International Edition Vol. 44; no. 15; pp. 2284 - 2288
Main Authors Gschösser, Sigrid, Gruber, Karl, Kratky, Christoph, Eichmüller, Christian, Kräutler, Bernhard
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 08.04.2005
WILEY‐VCH Verlag
Subjects
bioorganometallic chemistry
Cobamides - chemistry
Crystallography, X-Ray
DNA
Models, Molecular
Molecular Structure
molecular switches
Nucleotides - chemistry
RNA
RNA, Messenger - chemistry
Spectrophotometry, Ultraviolet
vitamin B12
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Summary:A vitamin that switches states: The appended nucleotide base B assists in the constitutional switch from the base‐on form of the B12 conjugate (blue, with a coordinated 5,6‐dimethylbenzimidazole (DMB) unit) to the base‐off form (red, with a free DMB unit). The process is strongly temperature dependent.
Bibliography:We would like to thank Prof. K.-H. Ongania for mass spectrometric analyses, Mag. Tea Pavkov for assistance in X-ray data collection, Dr. M. Fasching, Prof. R. Micura, and Dr. C. Höbartner for helpful discussions, and F. Hoffmann-La Roche & Co., Basel, for a generous gift of vitamin B12. We are also grateful to the Austrian National Science Foundation (FWF, project P13595), and the European Union (project EU-HPRN-CT-2002-00195) for support of our work.
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We are also grateful to the Austrian National Science Foundation (FWF, project P13595), and the European Union (project EU‐HPRN‐CT‐2002‐00195) for support of our work.
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We would like to thank Prof. K.‐H. Ongania for mass spectrometric analyses, Mag. Tea Pavkov for assistance in X‐ray data collection, Dr. M. Fasching, Prof. R. Micura, and Dr. C. Höbartner for helpful discussions, and F. Hoffmann‐La Roche & Co., Basel, for a generous gift of vitamin B
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200462085