Metallo-ROS in Alzheimer's Disease: Oxidation of Neurotransmitters by CuII-β-Amyloid and Neuropathology of the Disease

A clear mind: The CuII–β‐amyloid (Aβ) complex has been shown to exhibit enzyme‐like metal‐centered oxidative and hydroxylation catalyses. Metal‐centered oxidation of various neurotransmitters by CuAβ under biomimetic conditions has verified the bio‐relevance of the metal‐centered catalyses and is ex...

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Published inAngewandte Chemie International Edition Vol. 46; no. 18; pp. 3337 - 3341
Main Authors da Silva, Giordano F. Z., Ming, Li-June
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 27.04.2007
WILEY‐VCH Verlag
Subjects
Alzheimer Disease - metabolism
Alzheimer's disease
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
Catecholamines - chemistry
Catechols - chemistry
Cations, Divalent
copper
Copper - chemistry
Dopamine - chemistry
Hydrogen Peroxide - chemistry
Models, Chemical
Neurotic Disorders - metabolism
Neurotic Disorders - pathology
Neurotransmitter Agents - chemistry
Neurotransmitter Agents - metabolism
Organometallic Compounds - chemistry
Oxidation-Reduction
oxidoreductases
Oxidoreductases - chemistry
peptides
Reactive Oxygen Species - metabolism
redox chemistry
Sodium Dodecyl Sulfate - chemistry
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Summary:A clear mind: The CuII–β‐amyloid (Aβ) complex has been shown to exhibit enzyme‐like metal‐centered oxidative and hydroxylation catalyses. Metal‐centered oxidation of various neurotransmitters by CuAβ under biomimetic conditions has verified the bio‐relevance of the metal‐centered catalyses and is expected to provide a chemical basis for the better understanding of the etiology of Alzheimer's disease. ROS=reactive oxygen species.
Bibliography:istex:2A7EE5BEB1D02CDF59FB9159D86AA17F16BCB68F
The metallopeptide research is partially supported by the Petroleum Research Fund administrated by the American Chemical Society (number 40851-AC3). This Commincation is dedicated to the memory of Alois Alzheimer on the occasion of the centennial of the discovery of the disease (1906-2006).
ark:/67375/WNG-P5PL6XMB-W
ArticleID:ANIE200604421
Petroleum Research Fund - No. 40851-AC3
The metallopeptide research is partially supported by the Petroleum Research Fund administrated by the American Chemical Society (number 40851‐AC3). This Commincation is dedicated to the memory of Alois Alzheimer on the occasion of the centennial of the discovery of the disease (1906–2006).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200604421