Pharmaceutical Applications of Coriander in Neurodegenerative Disorders

• Published in: Handbook of Coriander (Coriandrum sativum) Vol. 1; pp. 175 - 186
• Main Authors: Sahoo, Swati, Sukumaran, Brijesh
• Format: Book Chapter
• Language: English
• Published: CRC Press 2023
• Edition: 1
• Subjects: epilepsy; Convulsion Models; Parkinson's disease; frontotemporal dementia; Als Treatment; amyotrophic lateral sclerosis; Nicotinic Acid Receptors; Mouse PD Model; cerebral ischemia; Total Thiol Concentration; Tar DNA Bind Protein; Alzheimer's disease; Larval Imaginal Disc; multiple sclerosis; Anti-Alzheimer's Activity; Ubiquitin Proteasome System Dysfunction; Huntington's disease; Ceo; Glutamate Pyruvate Transaminase Levels; Fresh Leaf Extracts; central nervous system; Oil; Coriander Seeds; Mutant SOD1; Cananga Odorata; Seed Essential Oil; Geranyl Acetate; Essential Oil; Open Arm Entries; spinocerebellar ataxia; Sativum Leaves
• ISBN: 9781032068527; 1032068523; 9781032069333; 1032069333
• DOI: 10.1201/9781003204626-14

Coriandrum sativum is a storehouse for bioactive compounds. Coriander seeds are rich in essential oils, and coriander essential oil is the second major annually produced oil following orange essential oil, indicating its importance as an economic spice. Apart from the seed essential oil, various fresh leaf extracts have been explored and studied for neurological activities. Coriandrum sativum is a promising functional food that demonstrates therapeutic impacts against neurodegenerative and behavioral disorders. This chapter reports on pharmaceutical applications of coriander in neurodegenerative disorders. This chapter reports on pharmaceutical applications of coriander in neurodegenerative disorders. Linalool, one of the major phytoconstituents of volatile coriander oil, has been reported for its antidepressant-like activity. Mahendra and Bisht demonstrated the anxiolytic effect of coriander seeds ethanol extract, wherein the animals treated with the extract (100 and 200 mg/kg) showed less anxiety-like behavior compared to the control animals in four anxiety models, viz., EPM, LDT, open field, and social interaction test. Karami et al. reported coriander's aerial parts' antioxidant and anticonvulsive effect (leaves, stems, and twigs). Linalool, an important phytoconstituent of coriander, has been reported to possess anticonvulsant activity by various studies. Also, coriander leaves have been reported to enhance the excretion of mercury following dental amalgam removal. Coriander seeds contain a high amount of essential oil, and coriander essential oil is the second major annually produced oil following orange essential oil, indicating its importance as an economic spice.