A 1H NMR spectroscopic study of the biochemical effects of ifosfamide in the rat: evaluation of potential biomarkers

Ifosfamide (55 mg kg-1 and 110 mg kg-1) was administered via single i.p. injections to Sprague-Dawley rats and urine samples were collected for the periods of -24-0, 0-8 h, 8-24 h, 24-48 h and 48-72 h post-dose. Quantitative changes in the excretion pattern of small organic molecules in the urine of...

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Bibliographic Details
Published inBiomarkers Vol. 5; no. 6; pp. 424 - 435
Main Authors LENZ, E. M, WILSON, I. D, TIMBRELL, J. A, NICHOLSON, J. K
Format Journal Article
LanguageEnglish
Published London Informa UK Ltd 2000
Taylor & Francis
Subjects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Ifosfamide 1h Nmr Spectroscopy Rat Creatine Testicular Toxicity
Medical sciences
Pharmacology. Drug treatments
Toxicity: urogenital system
Antineoplastic agent
Urine
Biological fluid
Intraperitoneal administration
Urinary system disease
Rat
Ifosfamide
Toxicity
Rodentia
Biological marker
NMR spectrometry
Testicle
Kidney
Vertebrata
Oxazaphosphinane derivatives
Mammalia
Animal
Nitrogen mustard
Male genital diseases
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Summary:Ifosfamide (55 mg kg-1 and 110 mg kg-1) was administered via single i.p. injections to Sprague-Dawley rats and urine samples were collected for the periods of -24-0, 0-8 h, 8-24 h, 24-48 h and 48-72 h post-dose. Quantitative changes in the excretion pattern of small organic molecules in the urine of rats treated with ifosfamide were studied using high frequency 1H NMR spectroscopy. The kidneys and livers of the animals were also examined, but showed no marked histopathological changes. 1
ISSN:1354-750X
1366-5804
DOI:10.1080/135475000750052439