Investigation the Binding Properties of Carbon-Dots as a Nanocarrier in Carbon-Dots - Gallic Acid Nanocomposite for Cancer Therapy

Cancer still poses a serious threat despite biomedical science advancements. However, the fast development of nanotechnology has opened a new ground in the field of nanomedicine for cancer treatment. In this study, we designed an anticancer nano-delivery system using organic Carbon-dots (CD) as nano...

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Bibliographic Details
Published in2023 1st International Conference on Health Science and Technology (ICHST) pp. 1 - 4
Main Authors Thuong, Quang-Tran, Phuong, Ly-Giang T, Dam, Quan-Nguyen
Format Conference Proceeding
LanguageEnglish
Published IEEE 28.12.2023
Subjects
Cancer treatment
Carbon
carbon-dots
Drugs
gallic acid
Nanobioscience
nanodelivery
Nuclear magnetic resonance
Spectroscopy
targeted drug delivery
X-ray scattering
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Summary:Cancer still poses a serious threat despite biomedical science advancements. However, the fast development of nanotechnology has opened a new ground in the field of nanomedicine for cancer treatment. In this study, we designed an anticancer nano-delivery system using organic Carbon-dots (CD) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (CDGA) was characterized using XRD, FTIR, SEM, NMR spectroscopy. In in vitro biological studies, human breast carcinoma (MCF-7), human hepatocarcinoma (HepG2), human gastric carcinoma (MKN-7), human colon carcinoma (HT-29) was treated with different concentrations of CD, GA, and CDGA. The CD successfully combined with GA, and the CD-GA nanocomposite showed cytotoxicity to the cancer cells. The results showed that carbon-dots is a potential candidate as a nanocarrier for cancer treatment, thus suggested further investigation with other pure anticancer drugs which has excellent anticancer activity.
DOI:10.1109/ICHST59286.2023.10565328