Marmoset

• Published in: Non-Clinical Vascular Infusion Technology, Two Volume Set pp. 513 - 534
• Format: Book Chapter
• Language: English
• Published: CRC Press 2014
• Subjects: Femoral Vein; Marmoset Monkey; Inhalation Anaesthesia; Above Ground; Restraining Devices; Adult Body Length; Surgical Models; Infusion Pumps; Vascular Access Ports; Middle Dorsum; Common Iliac Vein; Injection Anaesthesia; Flunixin Meglumine; Inguinal Region; Regulatory Toxicology Studies; Continuous Infusion; NHP; Vena Femoralis; Cynomolgus Monkey; IACUC; Catheter Tip; Callithrix Jacchus; Non-human Primate; Restraint Bed
• ISBN: 9781439874493; 1439874492
• DOI: 10.1201/b16370-28

The marmoset monkey is an alternative non-human primate model in drug development (Abbott et al. 2003; Mansfield 2003; Orsi et al. 2011; Korte et al. 2004) and has also been used as a model for induced Parkinson’s and Huntington’s diseases, multiple sclerosis, and rheumatoid arthritis8.4 Equipment ... 298 8.4.1 Surgical models ... 2988.4.1.1 Surgical facilities ... 298 8.4.1.2 Catheters/vascular access ports ... 299 8.4.1.3 External equipment ... 300 8.4.1.4 Infusion pumps ... 3008.4.2 Non-surgical models ... 301 8.4.2.1 Restraining devices ... 301 8.4.2.2 Vascular access ... 301 8.4.2.3 Infusion pumps ... 3018.5 Background data ... 302 8.5.1 Surgical models ... 3028.5.1.1 Complications associated with the surgical process ... 3028.5.1.2 In-life changes ... 302 8.5.1.3 Pathology ... 3038.6 Conclusion ... 303 References ... 305(Vierboom et al. 2010). For biopharmaceutical drugs, nonhuman primates are the relevant animal model in 80% of the cases (Chapman et al. 2007, 2009, 2010). When it comes to justifying using marmosets instead of macaques, tissue cross-reactivity evaluation may eliminate these other nonhuman primate (NHP) species, with the marmoset monkey remaining the only relevant model.