Pd0-Catalyzed Intramolecular α-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines

A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0‐catalyzed intramolecular α‐arylation of sulfones is reported. The combination of this Pd‐catalyzed reaction with intermolecular Michael and aza‐Michael reactions allows the development of two‐ and three‐step domino processe...

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Published inChemistry : a European journal Vol. 21; no. 12; pp. 4580 - 4584
Main Authors Solé, Daniel, Pérez-Janer, Ferran, Mancuso, Raffaella
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.03.2015
WILEY‐VCH Verlag
Subjects
arylation
domino reactions
nitrogen heterocycles
palladium
sulfones
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Summary:A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0‐catalyzed intramolecular α‐arylation of sulfones is reported. The combination of this Pd‐catalyzed reaction with intermolecular Michael and aza‐Michael reactions allows the development of two‐ and three‐step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0‐catalyzed intramolecular α‐arylation of sulfones is reported. The combination of this Pd‐catalyzed reaction with intermolecular Michael and aza‐Michael reactions allows the development of two‐ and three‐step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.
Bibliography:ark:/67375/WNG-9L0RZL8V-8
Spanish MINECO-FEDER - No. CTQ2012-31391
ArticleID:CHEM201406305
istex:9B0E1C06CD75581E7464BDF2A9AEF6143BF98FF2
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201406305