Indium(III)-coordination polymer based on a C3-symmetric ligand: crystal structure and anticancer activity on neuroblastoma

• Published in: Inorganic and nano-metal chemistry Vol. 50; no. 7; pp. 555 - 561
• Main Authors: Deng, Xingmei, Li, Chuanfeng, Pan, Yongming, Deng, Dan
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 02.07.2020
• Subjects: anti-proliferation activity; Coordination polymer; nanostructure; X-ray
• ISSN: 2470-1556; 2470-1564
• DOI: 10.1080/24701556.2020.1721022

By employment of a flexible pseudo C 3 -symmetric tricarboxylic acid 2,4,6-tris[(4-carboxyphenoxy)methyl]-1,3,5-trimethylbenzene (H 3 L), a new In(III)-containing coordination polymer with the chemical formula of {In(L)(H 2 O)](DMF)} n (1) has been successfully prepared by reaction of In(NO 3 ) 3 ·6H 2 O with the H 3 L in a mixed solvent of DMF and CH 3 CN with the HNO 3 as the pH modulator. The as-prepared complex 1 has been studied via the elemental analysis, powder X-ray diffraction, single crystal X-ray diffraction along with the thermogravimetric analysis. Furthermore, a sonochemical method was used to produce the nano-structures of complex 1. In biological functional study, the CCK-8 assay was performed to detect the in vitro anti-proliferation activity of nano 1. Then, the Annexin V-FITC/PI and DCFH-DA detection were performed to detect the cell apoptosis and intracellular ROS accumulation in SH-SY5Y neuroblastoma cells after compound treatment.