Direct evidence for the existence of Miltenbergera antigen

• Published in: Vox sanguinis Vol. 80; no. 4; pp. 230 - 233
• Main Authors: Chen, V., Halverson, G., Wasniowska, K., Lisowska, E., Chen, J., Moulds, M., Reid, M. E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.05.2001; Blackwell
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Fundamental and applied biological sciences. Psychology; Fundamental immunology; glycophorin; Immunohematology; Medical sciences; Miltenberger; MNS blood group system; monoclonal anti-Mia; Red blood cell immunology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Human; Antigenic determinant; MNS-System; Genetic variant; Rodentia; Red blood cell; Immunohematology; Monoclonal antibody; Antigen; Vertebrata; Blood group; Phenotype; Mammalia; Mouse; Animal; Glycophorine
• ISSN: 0042-9007; 1423-0410
• DOI: 10.1046/j.1423-0410.2001.00042.x

The Miltenberger (Mi) subsystem, which originally consisted of four phenotypes, now has 11 phenotypes. The antigens of this subsystem belong to the MNS blood group system. The Mia antigen has been reported to be present on red blood cells with several Miltenberger phenotypes, namely: Mi.I, Mi.II, Mi.III, Mi.IV, Mi.VI and Mi.X. However, the existence of the Mia antigen as a separate entity has been in question and difficult to prove with polyclonal reagents. We report the first monoclonal anti‐Mia (GAMA210), whose epitope is TNDKHKRD or QTNDMHKR, and thereby confirm the existence of the Mia antigen.