Fluctuation Dielectric Fourier Spectrometer for Estimation of Blood Cellular Components

• Published in: 2023 IEEE XVI International Scientific and Technical Conference Actual Problems of Electronic Instrument Engineering (APEIE) pp. 200 - 205
• Main Authors: Kovalev, Anton V., Kryukova, Olga V., Grinstein, Yury I., Soukhovolsky, Vladislav G., Maltseva, Anna N.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 10.11.2023
• Subjects: blood cells; cell membranes; device; dielectric characteristics; Dielectrics; Fluctuations; Instruments; Mice; Pathological processes; Software; Transforms
• ISSN: 2473-8573
• DOI: 10.1109/APEIE59731.2023.10347704

Α qualitative method for evaluating the condition of blood components using the dielectric properties of a blood sample is presented in the paper. The proposed scheme, unique software implementation, and design of a Fourier fluctuation dielectric spectrometer (FDFS) are described. With its assistance, it is possible to acquire the statistical distribution of blood components by membrane state in a short time frame of 10-15 seconds, enabling the qualitative evaluation of the entire circulatory system's functionality. An important property of the developed device is a small amount of the investigated blood sample (50-80µl). The author's experiments to assess the functional state of patients with ischemic heart disease and to examine the impact of Ehrlich ascites carcinoma on the blood of laboratory mice serve as examples of this study. It has been demonstrated that the proposed FRFS provides a speedy evaluation of changes in blood parameters during disease progression, as well as an elucidation of the dynamics of the tumor process in experimental animals.