A Microfluidic Device for Nano-scale Extracellular Vesicles Differentiation Via The Synergetic Effect of Deterministic Lateral Displacement and Dielectrophoresis

This paper proposes a novel microfluidic device based on the synergy of deterministic lateral displacement (DLD) and dielectrophoresis (DEP) techniques, which enables the differentiation of exosomes from both large extracellular vesicles (e.g. apoptotic vesicles, ectosomes) and particles that are cl...

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Bibliographic Details
Published in2023 IEEE 18th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) pp. 174 - 177
Main Authors Wang, Dayin, Zhao, Jianlong, Luo, Yuan
Format Conference Proceeding
LanguageEnglish
Published IEEE 14.05.2023
Subjects
Costs
Dielectrophoresis
Fabrication
Lithography
Nanoelectromechanical systems
Nanoscale devices
Oxidation
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Summary:This paper proposes a novel microfluidic device based on the synergy of deterministic lateral displacement (DLD) and dielectrophoresis (DEP) techniques, which enables the differentiation of exosomes from both large extracellular vesicles (e.g. apoptotic vesicles, ectosomes) and particles that are close in size but differ in biochemical compositions (e.g. Lipoproteins, Exomeres, Retroviruses). We fabricated nanoscale pillar arrays through \gt1 ~\mum resolution photolithography by making innovative use of thermal oxidation, which significantly reduces fabrication costs by avoiding the use of high-precision lithography. We further proceeded to optimize device design with simulation study and conduct experimental verification.
ISSN:2474-3755
DOI:10.1109/NEMS57332.2023.10190859