The effect of alternative diastolic pressure-volume relations on transmitral Doppler flow: comparison by model-based image processing

• Published in: Proceedings of the First Joint BMES/EMBS Conference : serving humanity advancing technology, Oct. 13-16, 99, Atlanta, GA, USA Vol. 1; pp. 220 vol.1 - 220
• Main Authors: Lisauskas, J.B., Kovacs, S.J.
• Format: Conference Proceeding Journal Article
• Language: English
• Published: IEEE 1999
• Subjects: Biophysics; Cardiology; Damping; Doppler effect; Filling; Image processing; Image restoration; Mathematical model; Mathematical models; Oscillators; Predictive models; Pressure measurement; Springs; Volume measurement
• ISBN: 0780356748; 9780780356740; 9780780356757; 0780356756
• ISSN: 1094-687X; 0589-1019; 1558-4615
• DOI: 10.1109/IEMBS.1999.802271

Several mathematical expressions (linear, exponential, logarithmic) have been used to fit the measured diastolic pressure-volume (P-V) relation. We determined whether the different P-V relations could be distinguished by analysis of in-vivo physiologic data. Transmitral Doppler E-waves of 15 subjects were analyzed using model-based image processing (MBIP). One dimensional linear, logarithmic, and exponential force displacement equivalents of the P-V relation were used in our lumped-parameter kinematic model of transmitral flow for MBIP. Minimized least-square best fits of model predicted to observed Doppler E-wave flow velocity were similar regardless of choice of mathematical expression. We conclude that application of the simplest P-V relation is justified in MBIP analysis of transmitral Doppler flow.