Evaluation of single nucleotide polymorphisms of angiotensin II type 2 receptor (AGTR2) gene and interleukin 4 (IL-4) gene for their contribution to the risk of preeclampsia in Turkish population

• Published in: Cukurova Medical Journal Vol. 42; no. 3; pp. 477 - 483
• Main Authors: Keser,Nurşen, Pazarbaşı,Ayfer, Özpak,Lütfiye, Yılmaz,Mehmet Bertan, Lüleyap,Hüsnü Ümit, Tuncay Özgünen,Fatime
• Format: Journal Article
• Language: English
• Published: Çukurova Üniversitesi Tıp Fakültesi 01.03.2017
• Subjects: Tıp; Türkiye; Adana; polimorfizm; Preeklampsi; Preeclampsia; IL-4; polymorphism; AGT2R; AGTR2
• ISSN: 2602-3032; 2602-3040
• DOI: 10.17826/cutf.297910

Purpose: Preeclampsia, specific to human pregnancies, is a serious disorder, which occurs approximately in 6-10% of all pregnancies. It is a complex disorder, in which immune and genetic factors also take part. The aim of the current study was toinvestigate whether there is an association between AGTR2 A1675G and IL4 -590 (C>T) polymorphisms and preeclampsia. Material and Methods: Genomic DNA was extracted from the peripheral venous blood of 131 preeclamptic and 86 normotensive pregnant women. The AGTR2 and IL-4 polymorphisms were genotyped by using a polymerase chain reaction assay. Results: As for AGTR2 gene 1675 polymorphism, there was not any significant difference in terms of genotype frequencies but there was a significant difference in terms of allele frequencies. As for IL-4 gene -590 polymorphism, there was not any significant difference in terms of genotype and allele frequencies. Conclusions: AGTR2, GG genotype and IL-4, TT genotype were found significantly higher in preeclamptic women than normotensive pregnant women.These genotypes might be a susceptibility risk factor for preeclampsia but these findings need to be tested in a larger sample size.