Comparison Of Calcitonin And Pamidronate Treatments In Children With Osteogenesis Imperfecta

Purpose: The main objective of this study was to compare the treatments of calcitonin and pamidronate by clinical, biochemical, and radiological findings in children with osteogenesis imperfecta and evaluate the efficiency of pamidronate treatment. Materials and Methods: A total of 12 patients, aged...

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Bibliographic Details
Published inCukurova Medical Journal Vol. 38; no. 4
Main Authors Gürbüz,Fatih, Topaloğlu,Ali Kemal, Yüksel,Bilgin, Mengen,Eda, Özgür,Özden
Format Journal Article
LanguageEnglish
Published Çukurova Üniversitesi Tıp Fakültesi 01.04.2013
Subjects
Tıp
Türkiye
Adana
pamidronate
pamidronat
kalsitonin
calcitonin
children
Osteogenesis imperfecta
Osteogenezis imperfekta
çocuklar
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Summary:Purpose: The main objective of this study was to compare the treatments of calcitonin and pamidronate by clinical, biochemical, and radiological findings in children with osteogenesis imperfecta and evaluate the efficiency of pamidronate treatment. Materials and Methods: A total of 12 patients, aged 41±38 (1-120) months were studied. Group 1 was consisted of six patients who had received intranasal calcitonin at a dosage of 4-6 U/kg three times a week before switching to pamidronate treatment. Group 2 was also consisted of six patients who had received only pamidronate infusion at a dosage of 0.5-2 mg/kg every two months. Results: Annual fracture rates decreased from 2.72 ± 0.80 to 0.40 ± 0.70 (p
ISSN:2602-3032
2602-3040