ChemInform Abstract: Synthesis and Pharmacological Evaluation of Novel Substituted 9-Deazaxanthines as A2B Receptor Antagonists

A series of novel 9‐deazaxanthine derivatives with various substituents at the heterocyclic system is synthesized and evaluated for binding affinities for the four human recombinant adenosine receptors, A1—A3 subtypes.

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Bibliographic Details
Published inChemInform Vol. 41; no. 42; p. no
Main Authors Nieto, Maria Isabel, Balo, Maria Carmen, Brea, Jose, Caamano, Olga, Fernandez, Franco, Garcia-Mera, Xerardo, Lopez, Carmen, Loza, Maria Isabel, Rodriguez-Borges, Jose Enrique, Vidal, Bernat
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 19.10.2010
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
fused pyrimidine derivatives
receptor binding activity
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Summary:A series of novel 9‐deazaxanthine derivatives with various substituents at the heterocyclic system is synthesized and evaluated for binding affinities for the four human recombinant adenosine receptors, A1—A3 subtypes.
Bibliography:ark:/67375/WNG-8R5CJPV2-M
istex:F23C9F4B7A3C8AD46FD18F346744D235E7A5D9EA
ArticleID:CHIN201042223
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201042223