Biological Effects of 125I Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death

External beam radiation (EBRT) and 125I seeds continuous low dose rate radiation (CLDR) were used to treat patients with lung cancer. We herein investigated the biological effects of EBRT and CLDR on lung cancer cells. A549 human lung cancer cell line was thus exposed to different doses of EBRT and...

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Bibliographic Details
Published inCancer investigation Vol. 32; no. 6; pp. 209 - 217
Main Authors Qu, Ang, Wang, Hao, Li, Jinna, Wang, Junjie, Liu, Jingjia, Hou, Yuzhu, Huang, Li, Zhao, Yong
Format Journal Article
LanguageEnglish
Published Informa Healthcare 03.07.2014
Taylor & Francis
Subjects
125I continuous low dose rate radiation
DNA double-strand breaks
Lung cancer
Single external beam radiation
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Summary:External beam radiation (EBRT) and 125I seeds continuous low dose rate radiation (CLDR) were used to treat patients with lung cancer. We herein investigated the biological effects of EBRT and CLDR on lung cancer cells. A549 human lung cancer cell line was thus exposed to different doses of EBRT and CLDR. CLDR was more efficient to inhibit cell growth than EBRT. CLDR induced increased DNA damage as evidenced by long-lasting p-H2AX activity. The enhanced inhibitory effects of CLDR on lung cancer cell growth may be, at least in part, due to the increased Bax/Bcl2 ratio and cyclin B1-mediated G2/M arrest.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2014.905585