Synthesis of 3,4,3 LI 1,2 HOPO labelled with 14C

3,4,3 LI 1,2 HOPO 1 or LIHOPO (1,5,10,14‐tetra (1‐hydroxy‐2‐pyridone‐6‐oyl)‐1,5,10,14‐tetraazatetradecane.) is a decorporation agent used against actinides. It was synthesised labelled with carbon 14 with a view to metabolism studies. [6,9‐14C]‐LIHOPO 2 was obtained in two radioactive steps through...

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Published inJournal of labelled compounds & radiopharmaceuticals Vol. 44; no. 1; pp. 13 - 19
Main Authors Burgada, R., Bailly, T., Noël, J. P., Gomis, J. M., Valleix, A., Ansoborlo, E., Hengé-Napoli, M. H., Paquet, F., Gourmelon, P.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.01.2001
Wiley
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Summary:3,4,3 LI 1,2 HOPO 1 or LIHOPO (1,5,10,14‐tetra (1‐hydroxy‐2‐pyridone‐6‐oyl)‐1,5,10,14‐tetraazatetradecane.) is a decorporation agent used against actinides. It was synthesised labelled with carbon 14 with a view to metabolism studies. [6,9‐14C]‐LIHOPO 2 was obtained in two radioactive steps through a very convenient synthesis in 50% radioactive yield from commercially available [1,4‐14C]‐spermine, hydrochloride and 1‐benzyloxy‐6‐oxo‐1,6‐dihydropyridine‐2‐carbonyl chloride 7. The synthesis of 7 is also described. Copyright © 2001 John Wiley & Sons, Ltd.
Bibliography:ark:/67375/WNG-MH8HNVPP-N
istex:F083BB67C496C44BFD322BCEFDCEA1FB67CD8DEA
ArticleID:JLCR427
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.427