Synthesis of 3,4,3 LI 1,2 HOPO labelled with 14C
3,4,3 LI 1,2 HOPO 1 or LIHOPO (1,5,10,14‐tetra (1‐hydroxy‐2‐pyridone‐6‐oyl)‐1,5,10,14‐tetraazatetradecane.) is a decorporation agent used against actinides. It was synthesised labelled with carbon 14 with a view to metabolism studies. [6,9‐14C]‐LIHOPO 2 was obtained in two radioactive steps through...
Saved in:
Published in | Journal of labelled compounds & radiopharmaceuticals Vol. 44; no. 1; pp. 13 - 19 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.01.2001
Wiley |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | 3,4,3 LI 1,2 HOPO 1 or LIHOPO (1,5,10,14‐tetra (1‐hydroxy‐2‐pyridone‐6‐oyl)‐1,5,10,14‐tetraazatetradecane.) is a decorporation agent used against actinides. It was synthesised labelled with carbon 14 with a view to metabolism studies. [6,9‐14C]‐LIHOPO 2 was obtained in two radioactive steps through a very convenient synthesis in 50% radioactive yield from commercially available [1,4‐14C]‐spermine, hydrochloride and 1‐benzyloxy‐6‐oxo‐1,6‐dihydropyridine‐2‐carbonyl chloride 7. The synthesis of 7 is also described. Copyright © 2001 John Wiley & Sons, Ltd. |
---|---|
Bibliography: | ark:/67375/WNG-MH8HNVPP-N istex:F083BB67C496C44BFD322BCEFDCEA1FB67CD8DEA ArticleID:JLCR427 |
ISSN: | 0362-4803 1099-1344 |
DOI: | 10.1002/jlcr.427 |