SYNTHESIS AND BASE PAIRING PROPERTIES OF 9-DEAZAPURINE N7-NUCLEOSIDES IN OLIGONUCLEOTIDE DUPLEXES AND TRIPLEXES

The 9-deazaguanine N 7 -2′-deoxyribofuranoside (3) as well as the bromo and iodo derivatives 4a,b were synthesized and incorporated in oligonculeotide duplexes and triplexes. Their base pairing properties were investigated and compared with those of the parent purine N 7 -2′-deoxyribofuanosides.

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Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 20; no. 4-7; pp. 1279 - 1282
Main Authors Leonard, P., Wiglenda, T., Seela, F.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis Group 01.04.2001
Subjects
Base Pairing
DNA - chemistry
Glycosylation
Guanine - analogs & derivatives
Guanine - chemical synthesis
Guanine - chemistry
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Purine Nucleosides - chemical synthesis
Purine Nucleosides - chemistry
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Summary:The 9-deazaguanine N 7 -2′-deoxyribofuranoside (3) as well as the bromo and iodo derivatives 4a,b were synthesized and incorporated in oligonculeotide duplexes and triplexes. Their base pairing properties were investigated and compared with those of the parent purine N 7 -2′-deoxyribofuanosides.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-100002536