Assessing sub-Saharan Erythrina for efficacy: traditional uses, biological activities and phytochemistry

• Published in: Pakistan journal of biological sciences Vol. 14; no. 10; pp. 560 - 571
• Main Authors: Kone, Witabouna Mamidou, Solange, Kakou-Ngazoa E, Dosso, Mireille
• Format: Journal Article
• Language: English
• Published: Pakistan Asian Network for Scientific Information (ANSINET) 15.05.2011
• Subjects: Africa South of the Sahara; Animals; Bacteriology; Erythrina; Erythrina - chemistry; Humans; Life Sciences; Medicine, African Traditional; Microbiology and Parasitology; Molecular Structure; Phytotherapy; Plant Extracts; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Plants, Medicinal; Plants, Medicinal - chemistry; Africa South of the Sahara; Erythrina; metabolic diseases; bioactive compouds; Sub-saharian Africa; infectious diseases
• ISSN: 1028-8880; 1812-5735
• DOI: 10.3923/pjbs.2011.560.571

The genus Erythrina comprises more than 100 species, widely distributed in tropical and subtropical areas. In Africa, 31 wild species and 14 cultivated species have been described. In sub-Saharan Africa, Erythrina species are used to treat frequent parasitic and microbial diseases, inflammation, cancer, wounds. The rationale of these traditional uses in African traditional medicine was established by screening several species for biological activities. Promising activities were found against bacteria, parasites (Plasmodium), human and phytopathogenic fungi, some of which were multidrug resistant (MDR) micro organisms. Some species also exhibited antioxidant, anti-inflammatory activities and enzymes inhibitory properties. Most of the species chemically investigated were reported to contain flavanones, prenylated isoflavones, isoflavanones and pterocarpans. Some phytochemicals (vogelin B, vogelin C, isowightcone, abyssinin II, derrone) were the active principles as antibacterials, antifungals, antiplasmodials and inhibitors of enzyme borne diseases (PTP1B, HIV protease, DGAT). This review highlights the important role of Erythrina species as sources of lead compounds or new class of phytotherapeutic agents for fighting against major public health (MDR infections, cancer, diabetes, obesity) in sub-Saharan Africa.