Interleukin-1beta (IL-1beta) induces a crosstalk between cAMP and ceramide signaling pathways in thyroid epithelial cells

• Published in: Biochimie Vol. 87; no. 12; pp. 1121 - 1126
• Main Authors: Schneider, C, Rath, G M, Delorme, N, El Btaouri, H, Hornebeck, W, Martiny, L
• Format: Journal Article
• Language: English
• Published: France Elsevier 01.12.2005
• Subjects: Animals; Ceramides - physiology; Cyclic AMP - physiology; Epithelial Cells - drug effects; Epithelial Cells - physiology; Interleukin-1 - pharmacology; Kinetics; Pertussis Toxin - pharmacology; Signal Transduction - drug effects; Sphingomyelin Phosphodiesterase - metabolism; Swine; Thyroid Gland - cytology; Thyroid Gland - drug effects; Thyroid Gland - physiology
• ISSN: 0300-9084; 1638-6183

Interleukin-1 beta (IL-1beta) is an important regulator of the thyroid cell function. This cytokine has been largely described to trigger an important biological signaling cascade: the sphingomyelin/ceramide pathway. In this report, we show that IL-1beta induces the transient activation of a neutral sphingomyelinase in porcine thyroid cells. Moreover, IL-1beta and ceramides are demonstrated to inhibit the TSH-induced cAMP production via the implication of alphaGi subunit of the adenylyl cyclase system. This crosstalk between cAMP and ceramide pathways constitutes a preponderant process in the TSH-controlled differentiation state of thyrocytes. All these results argue for the involvement of ceramides and IL-1beta in the thyroid function regulation, leading to a cell dedifferentiated state.