Effect of aerobic exercise training on adipose tissue hypoxia and inflammation in obesity

Background. Current research has begun to examine adipose hypoxia as a possible mechanism for obesity-related chronic inflammation. Purpose. The purpose of this study was to investigate the effects of aerobic exercise training on adipose tissue hypoxia and inflammation in obese rats. Methods. Twenty...

Full description

Saved in:
Bibliographic Details
Main Author DiSanzo, Beth L
Format Dissertation
LanguageEnglish
Published ProQuest Dissertations & Theses 01.01.2010
Subjects
Kinesiology
Physiology
Online AccessGet full text

Cover

More Information
Summary:Background. Current research has begun to examine adipose hypoxia as a possible mechanism for obesity-related chronic inflammation. Purpose. The purpose of this study was to investigate the effects of aerobic exercise training on adipose tissue hypoxia and inflammation in obese rats. Methods. Twenty-three obese and lean Zucker rats received either 8 weeks of aerobic exercise training or sedentary lifestyle. Epididymal adipose tissue samples were collected for analysis. Results. Adipose capillary density (P<.05) was higher, whereas body weight (P<.05), adipose lactate (P<.05) and monocyte chemoattractant protein-1MCP-1), (P<.05) were lower in the exercise training versus sedentary group in obese rats. Conclusion. These results show that aerobic exercise training may be an effective way to increase capillary density and decrease adipose tissue hypoxia and inflammation in obesity.
ISBN:9781124244167
1124244166