Activity-dependent synaptic plasticity of NMDA receptors

Activity-dependent, bidirectional control of synaptic efficacy is thought to contribute to many forms of experience-dependent plasticity, including learning and memory. Although most excitatory synapses contain both AMPA and N -methyl- d -aspartate receptors (AMPARs and NMDARs), most studies have fo...

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Published inThe Journal of physiology Vol. 588; no. 1; pp. 93 - 99
Main Authors Rebola, Nelson, Srikumar, Bettadapura N., Mulle, Christophe
Format Journal Article
LanguageEnglish
Published Oxford, UK The Physiological Society 01.01.2010
Blackwell Publishing Ltd
Wiley Subscription Services, Inc
Blackwell Science Inc
Subjects
Action Potentials - physiology
Aging - physiology
Animals
Biological Clocks - physiology
Brain - physiology
Humans
Models, Neurological
Nerve Net - physiology
Neuronal Plasticity - physiology
Neurons - physiology
Receptors, N-Methyl-D-Aspartate - metabolism
Symposium Section Reviews: Neurophysiology of Inhibitory and Excitatory Amino Acid Receptors
Synaptic Transmission - physiology
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Summary:Activity-dependent, bidirectional control of synaptic efficacy is thought to contribute to many forms of experience-dependent plasticity, including learning and memory. Although most excitatory synapses contain both AMPA and N -methyl- d -aspartate receptors (AMPARs and NMDARs), most studies have focused on the plasticity of synaptic AMPARs, and on the pivotal role of NMDA receptors for its induction. Here we review evidence that synaptic NMDARs themselves are subject to long-term activity-dependent changes by mechanisms that may differ from that of synaptic AMPARs. The bidirectional modulation of NMDAR-mediated synaptic responses is likely to have important functional implications for NMDAR-dependent forms of synaptic plasticity.
Bibliography:This review was presented at a symposium on
which took place at the 11th International Congress on Amino Acids, Peptides and Proteins, Vienna, on 3 August 2009.
Neurophysiology of inhibitory & excitatory amino acid receptors
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This review was presented at a symposium on Neurophysiology of inhibitory & excitatory amino acid receptors which took place at the 11th International Congress on Amino Acids, Peptides and Proteins, Vienna, on 3 August 2009.
ISSN:0022-3751
1469-7793
1469-7793
DOI:10.1113/jphysiol.2009.179382