Checking your SOCCs and feet: the molecular mechanisms of Ca2+ entry in skeletal muscle
It has long been known that skeletal muscle contraction persists in the absence of extracellular Ca 2+ . Nevertheless, recent evidence indicates that multiple distinct Ca 2+ entry pathways exist in skeletal muscle: one active at negative potentials that requires store depletion (store-operated calci...
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Published in | The Journal of physiology Vol. 587; no. 13; pp. 3139 - 3147 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
The Physiological Society
01.07.2009
Blackwell Publishing Ltd Blackwell Science Inc |
Subjects | |
Online Access | Get full text |
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Summary: | It has long been known that skeletal muscle contraction persists in the absence of extracellular Ca 2+ . Nevertheless, recent evidence indicates that multiple distinct Ca 2+ entry pathways exist in skeletal muscle: one active at negative potentials that requires store depletion (store-operated
calcium entry or SOCE) and a second that is independent of store depletion and is activated by depolarization (excitation-coupled
calcium entry or ECCE). This review highlights recent findings regarding the molecular identity, subcellular localization,
and inter-relationship between SOCE and ECCE in skeletal muscle. The respective roles of ryanodine receptors (RyRs), dihydropyridine
receptors (DHPRs), inositol-1,4,5-trisphosphate receptors (IP 3 Rs), canonical transient receptor potential channels (TRPCs), STIM1 Ca 2+ sensor proteins, and Orai1 Ca 2+ permeable channels in mediating SOCE and ECCE in skeletal muscle are discussed. Differences between SOCE and ECCE in skeletal
muscle with Ca 2+ entry mechanisms in non-excitable cells are also reviewed. Finally, potential physiological roles for SOCE and ECCE in skeletal
muscle development and function, as well as other currently unanswered questions and controversies in the field are also considered. |
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Bibliography: | The Journal of Physiology which took place at the 53rd Biophysical Society Annual Meeting at Boston, MA, USA on 27 February 2009. It was commissioned by the Editorial Board and reflects the views of the authors. This review was presented at Calsequestrin, triadin and more: the proteins that modulate calcium release in cardiac and skeletal muscle Symposium on ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 This review was presented at The Journal of Physiology Symposium on Calsequestrin, triadin and more: the proteins that modulate calcium release in cardiac and skeletal muscle, which took place at the 53rd Biophysical Society Annual Meeting at Boston, MA, USA on 27 February 2009. It was commissioned by the Editorial Board and reflects the views of the authors. |
ISSN: | 0022-3751 1469-7793 |
DOI: | 10.1113/jphysiol.2009.172148 |