Extracting the Groupwise Core Structural Connectivity Network: Bridging Statistical and Graph-Theoretical Approaches

• Published in: Information Processing in Medical Imaging Vol. 10265; pp. 373 - 384
• Main Author: Niethammer, Marc
• Format: Book Chapter
• Language: English
• Published: Switzerland Springer International Publishing AG 2017; Springer International Publishing
• Series: Lecture Notes in Computer Science
• Subjects: Brain connectivity; Core graph problem; Diffusion MRI; Group-wise connectome
• ISBN: 9783319590493; 3319590499
• ISSN: 0302-9743; 1611-3349
• DOI: 10.1007/978-3-319-59050-9_30

Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuroscience. Recent evidence suggests there’s a tightly connected network shared between humans. Obtaining this network will, among many advantages, allow us to focus cognitive and clinical analyses on common connections, thus increasing their statistical power. In turn, knowledge about the common network will facilitate novel analyses to understand the structure-function relationship in the brain. In this work, we present a new algorithm for computing the core structural connectivity network of a subject sample combining graph theory and statistics. Our algorithm works in accordance with novel evidence on brain topology. We analyze the problem theoretically and prove its complexity. Using 309 subjects, we show its advantages when used as a feature selection for connectivity analysis on populations, outperforming the current approaches.