Increased p53 mutation frequency during tumor progression-results from a breast cancer cohort

• Published in: Cancer research (Chicago, Ill.) Vol. 61; no. 22; pp. 8317 - 8321
• Main Authors: NORBERG, Torbjörn, KLAAR, Sigrid, KÄRF, Gunilla, NORDGREN, Hans, HOLMBERG, Lars, BERGH, Jonas
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.11.2001
• Subjects: Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cohort Studies; Disease Progression; Female; Genes, p53 - genetics; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Medicin och hälsovetenskap; Mutation; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Tumors; Human; Relapse; Nucleotide sequence; Pathogenesis; Malignant tumor; Epidemiology; Mammary gland diseases; TP53 Gene; Cohort study; Tumor progression; Female; Mammary gland; Mutation; Tumor suppressor gene
• ISSN: 0008-5472; 1538-7445

The mutational patterns of the p53 gene for exons 4-9 were analyzed in 30 recurring tumors compared with the p53 status of the corresponding 30 primary breast cancers. The prevalence of p53 mutations was higher, although not statistically significant (P = 0.07), in the evaluable recurring tumors compared with the corresponding primaries, 12 of 29 (41%) versus 7 of 30 (23%). Twenty-one of the patients had unchanged p53 mutation status in the recurring compared with the primary tumors, whereas 8 had an altered mutational status or pattern in the sequential tumor. These findings indicate that p53 mutations may be an important factor for tumor progression in human breast cancer.