Comparative automated assay of anti-P1 antibodies in acute hepatic distomiasis (fascioliasis) and in hydatidosis

• Published in: Vox sanguinis Vol. 38; no. 3; p. 165
• Main Authors: Ben-Ismail, R, Rouger, P, Carme, B, Gentilini, M, Salmon, C
• Format: Journal Article
• Language: English
• Published: England 01.01.1980
• Subjects: Autoanalysis; Blood Group Antigens; Echinococcosis - blood; Echinococcosis - immunology; Fascioliasis - blood; Fascioliasis - immunology; Humans; Isoantibodies - immunology; P Blood-Group System; Phenotype
• DOI: 10.1111/j.1423-0410.1980.tb02345.x
• ISSN: 0042-9007

An automated assay of anti-P1 allohemagglutinins has been carried out on 133 P2 subjects: 13 with acute hepatic distomiasis (Fascioliasis), 20 with hydatidosis and 100 healthy blood donors. Anti-P1 were detected in 100% of the distomatid sera, in 50% of the hydatid and in 29% of the healthy individuals. When compared to a reference serum test (anti-P1 standard), their concentration was found to be weak in healthy subjects, moderate in hydatidosis and exceptionally increased in acute distomiasis (up to 5-6 times the standard anti-P1 level). The 2-mercaptoethanol treatment showed that even the increased distomatid anti-P1 sera were of an IgM nature. The respective origin, synthesis and strength of these allohemagglutinins are discussed and the advantages of using distomatid IgM anti-P1 as human sera test are emphasized.